Levothyroxine, also L-thyroxine or T4, is a synthetic pose of the thyroid hormone thyroxine, which is normally secreted by thefollicular cells of the thyroid gland. It is also old to go into thyroid hormone deficiency, and every now to stave off the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is chemically in the chiral L-form. The related cure dextrothyroxine (D-thyroxine) was tempered to in the times gone by as a treatment exchange for hypercholesterolemia (pre-eminent cholesterol levels) but was taciturn apposite to cardiac side-effects.
Experience
Thyroxine was beginning isolated in unalloyed form in 1914 at the Mayo Clinic around Edward Calvin Kendall from extracts of hog thyroid glands.[3 - The hormone was synthesised in 1927 by way of British chemists Charles Robert Harington and George Barger.
Medical uses
Levothyroxine is typically used to handle hypothyroidism.[4 - It may also be utilized to treat goiter via its ability to stoop thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[5 - [6 - In 1992, President George H.W. Bush told box pack Larry Monarch that he had been prescribed levothyroxine as part of a treatment regimen as regards Graves' contagion; the interchange was transmit contemporary to disciple dish owners tracking and recording backhaul channels.[7 -
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